From: Robert Trivers <
To: Alan Rogers 5 >, Jeffrey Epstein <jeevacation®gmail.com>
Cc: Gordon Gett , Oliver Goodenou h
Tim Kane Rob Hanson
, Bobby McCormick
, Clive Crook , Matt Ridl
, Gerry Ohrstrom , Lee Silver
Monika Gruter Chene , Dane Stan ler
Ron Baile , Anna Dreber a
Paul Romer Mike Ca
, Evan Smith , Roger Edelen
Bill Prezant John Mallen
Jim Halligan Ma cuerite Atkins
, "Alex.Family Pines" , Ditsa Pines
, David Darst
Clair Brown < , "Ms. Yvette Robbins"
"Richerson, Peter J" <
Subject: Re: Free Growth (09-29-17) part 2.pdf
Date: Sat, 14 Apr 2018 17:06:12 +0000
yes Alan i think you are
you are referring to duplication of a gene—there are many such genes including those produced by
retrotransposons (as evidenced by lack of introns)—where a gene has two separate effects and there is an
advantage to having a gene with each effect you will often prefer two genes to one, because of less interference
in fitness effects
Peter was talking about a gene with a single effect—sickling—and the other allele is the normal one—the
heterozygote destroys malaria within red blood cells at trivial cost and there is no cost at all if malaria is not
present—by contrast homozygous sickle individuals suffer lifetime effects
Peter was trying to conjure up a heterozygote that propagated asexually but this requires a chiasma between
neighbouring genes, a very rare event and hence it usually leads rapidly to mutational decay of one of the two
copies, i.e. so-called pseudogenes, of which there are many in our genome
in haste
On Thu, Apr 12, 2018 at 11:02 PM, Alan Rogers <1 > wrote:
I haven't read whatever Pete wrote, but if I understand Bob correctly,
Pete must be talking about subfunctionalization:
https://en.wikipedia.org/wiki/Subfunctionalization
If so, it's not a radical suggestion. It's thought to be the process that
gave rise to all multi-gene families. Michael Lynch discusses it in his
book, The Origin of Genome Architecture.
Am I missing something?
EFTA00832044
Alan
On Thu, Apr 12, 2018 at 3:03 PM, Robert Trivers < > wrote:
here is my latest and final comment on Peter Richerson's comments on Gordon's idea about Trump being a
narcissistic psychopath—a view with which i firmly agree
i have learned a lot by thinking through all of Peter's argumentation but i have not learned much that
contradicts either my biases nor reality herself
all best wishes
On Fri, Sep 29, 2017 at 5:26 PM, Gordon Getty < > wrote:
Friends and Family,
Here's my latest on free growth theory. Tell me if I'm making any progress in my old intelligibility deficit.
I'm also working on a new version without math.
EFTA00832045