From:
To: Jeffrey Epstein <jeevacation@gmail.com>
Subject: Fwd: article from Ed Boyden on using gamma frequency stimulation to attenuate amyloid
load
Date: Thu, 20 Jul 2017 11:47:15 +0000
Attachments: nature20587.pdf
Currently the optogenetics stuff is extracranial and very invasive
Might be better to approach endovascular / noninvasive
Begin forwarded message:
From: Philip Eckhoff >
Date: July 20.2017 at 5:38:14 AM GMT+1
To:
Subject: article from Ed Boyden on using gainma frequent) stimulation to attenuate amyloid load
Dear all,
Each year I interview about half of the finalists for the Hertz Fellowship, and one of my co-
interviewers is Ed Boyden at MIT. Over lunch between interviews, it is always fun and fascinating to
hear about what he is working on at present. This past spring, one of the projects I heard about was
about stimulating gamma oscillations in mice brains and the corresponding impact on amyloid load
and plaque formation (and microglia). They did it optogenetically and saw a strong effect at 40 Hz,
and then they did it just with flickering light at 40 Hz. Pretty cool result, and will be interesting to see
where it goes. http://www.nature.comMature/joumal/v540/n7632/full/nature20587.html
Paper attached.
Best,
Philip
EFTA01039994