From
To: Jeffrey Epstein .cleevacation@gmail.com>
Subject: parkinsons
Date: Thu, 22 Jun 2017 04:38:52 +0000
In Parkinsons disease the protein aggregate is called alpha synuclein. Some neat
research that shows the protein aggregates to be dependent on intracellular pH.
Still think that the proteins may or may not have anything to do with the pathology. They
could be a good marker in some way.
(see below)
Mitochondrial translocation of a-synuclein is promoted by
intracellular acidification
Mitochondrial dysfunction plays a central role in the selective vulnerability of
dopaminergic
neurons in Parkinson's disease (PD) and is influenced by both environmental and genetic
factors. Expression of the PD protein o-synuclein or its familial mutants often sensitizes
neurons
to oxidative stress and to damage by mitochondrial toxins. This effect is thought to be
indirect,
since little evidence physically linking o-synuclein tomitochondria has been reported.
Here,we
show that the distribution of a-synuclein within neuronal and non-neuronal cells is
dependent
on intracellular pH. Cytosolic acidification induces translocation of a-synuclein fromthe
cytosol
onto the surface of mitochondria.
EFTA01042996