From•
To: Jeffrey Epstein <jeevacation@gmail.com>
Subject: aggregation and degeneration
Date: Mon, 10 Apr 2017 23:41:29 +0000
I think these all have a more common origin than we thought...involves vagus and stress
to the system. Different stressors hit different parts of the system. More when I see you.
The approach to prevent and treat would be radically different from what is happening
now.
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD),
amyotrophic lateral sclerosis (ALS) and prlon diseases are increasingly being realized to have common cellular and
molecular mechanisms including protein aggregation and inclusion body formation. The aggregates usually consist of
fibers containing misfolded protein with a ,eta-sheet conformation, termed amylold. There Is partial but not perfect
overlap among the cells in which abnormal proteins are deposited and the cells that degenerate. The most likely
explanation is that inclusions and other visible protein aggregates represent an end stage of a molecular cascade of
several steps, and that earlier steps in the cascade may be more directly tied to pathogenesis than the inclusions
themselves. For several diseases, genetic variants assist in explaining the pathogenesis of the more common sporadic
forms and developing mouse and other models. There is now increased understanding of the pathways Involved in
protein aggregation, and some recent clues have emerged as to the molecular mechanisms of cellular toxicity. These
are leading to approaches toward rational therapeutics.
EFTA01049971