EFTA00506157Set 9
46p3,296w
EFTA00506163
Ovation Therapeutics
DACARI C API I AL I-LC7
EFTA00506164
Ovation Therapeutics
Monoclonal Polyclonal
•
Multivalency
Increased avidity
Increased potency
Increased effector function
DACARTGAPIIAL LLC,
EFTA00506165
Ovation Therapeutics
• Next-generation ... antibody therapy
• Monoclonals are big ($26B in 2010), polyclonals are
better
• Polyclonal production available in Q4, 2012
• "Killer app" in hospital acquired infections
$25M needed to reach $200M enterprise value ... Ovation Therapeutics
■ What Is It?
Ovation has a proprietary platform to create next-generation polyclonal antibody
therapeutics and improved monoclonal antibody therapeutics.
■ How Does It Work?
Ovation's genetically modified
https://www.justice.gov/epstein/files/DataSet%209/EFTA00506157.pdf
EFTA00506107Set 9
49p3,212w
CArt !AL LLC2
EFTA00506136
Products Deposited in Eggs
DAGAI,T,APITAL LLC
EFTA00506137
Polyclonal Antibodies
Monoclonal Polyclonal
• In
Di.Cnar Cnrirni ttc
in k
Multivalency
Increased avidity
ncrea sed p
efroetectnocry ... several multi-billion dollar markets.
• Huge market opportunity
• Enzyme Replacement Therapy - $15.0 B
• Polyclonal Antibodies: c. difficile, MRSA - $10.0 B
• Factor VII Deficiency - $5.8 B
$25M needed to reach $200M ... novel manufacturing methods for the production of therapeutic
enzymes, and human sequence monoclonal and polyclonal antibodies.
• How Does It Work?
OvationBio selects the most active and effective protein
https://www.justice.gov/epstein/files/DataSet%209/EFTA00506107.pdf
EFTA02295528Set 11
49p3,041w
EFTA_R1_01138831
EFTA02295557
Products Deposited in Eggs
ovItluCt
EFTA_R1_01136932
EFTA02295558
Polyclonal Antibodies
If?
Monoclonal Polyclonal
Multivalency
Increased avidity
Increased potency
Increased effector function
DAAIRTCP,FIT/NA ... several multi-billion dollar markets.
Huge market opportunity
• Enzyme Replacement Therapy - $15.0 B
• Polyclonal Antibodies: c. difficile, MRSA - $10.0 B
• Factor VII Deficiency - $5.8 B
$25M needed to reach $200M ... novel manufacturing methods for the production of
therapeutic enzymes, and human sequence monoclonal and polyclonal
antibodies.
• How Does It Work?
OvationBio selects the most active and effective protein
https://www.justice.gov/epstein/files/DataSet%2011/EFTA02295528.pdf