EFTA00603737Set 9
17p11,455w
three-dimensional architecture of a tumour, sional lattice (Extended Data Fig. 2a, b). Cells replicate stochastically
and come to dominate a large, pre-existing lesion, has been with rates proportional ... Limited. Al rights reserved
EFTA00603737
RESEARCH LETTER
(non- neoplastic cells or extracellular matrix), hence replication is Non-spatial models point to the size of a tumour as a crucial deter ... cancer cell whether a spatial model would similarly predict this dependency in
neighbours replicates at the maximal rate of b = In(2) = 0.69 days-I, a clinically relevant time frame
https://www.justice.gov/epstein/files/DataSet%209/EFTA00603737.pdf
EFTA00630326Set 9
2012-05-152p935w
Jeffrey,
My article today on Martin Novak's RNA replication work, got picked up by The Wall St. Journal, Reuters and CNBC
amongst others. See links:
Reuters: http://www.reuters.com/article/2012/05/14/idUS233533+14-May-2012+PRN20120514 ... many thanks,
Christina
PS: below is the text from my last article on RNA replication:
NEW YORK, May 14, 2012 /PRNewswire/ — The Program for Evolutionary Dynamics at Harvard University, announced ... link between chemical
kinetics and when life takes over.
"Prelife morphs into life when replication occurs," Martin Novak asserted, Director of the Program for Evolutionary
Dynamics and Professor of Mathematics
https://www.justice.gov/epstein/files/DataSet%209/EFTA00630326.pdf
EFTA00935083Set 9
2012-05-153p1,118w
wrote:
Hi Jeffrey,
My article today on Martin Novak's RNA replication work, got picked up by The Wall St. Journal, Reuters and CNBC
amongst others. See links:
Reuters ... appreciative.
many thanks,
PS: below is the text from my last article on RNA replication:
NEW YORK, May 14, 2012 /PRNewswire/ — The Program for Evolutionary Dynamics at Harvard University, announced ... link between chemical
kinetics and when life takes over.
"Prelife morphs into life when replication occurs," Martin Novak asserted, Director of the Program for Evolutionary
Dynamics and Professor of Mathematics
https://www.justice.gov/epstein/files/DataSet%209/EFTA00935083.pdf
EFTA02016026Set 10
2012-05-143p935w
Subject: thank you
Hi Jeffrey,
`.article today on Martin Novak's RNA replication work, got picked up by The Wall St. Journal,
Reuters and CNBC amongst others. See links:
Reuters ... that I am
appreciative.
many thanks,
PS: below is the text article on RNA replication:
NEW YORK, May 14, 2012 /PRNewswire/ — The Program for Evolutionary Dynamics at Harvard
University, announced ... link between chemical kinetics and when life takes over.
"Prelife morphs into life when replication occurs," Martin Novak asserted, Director of the Program for
Evolutionary Dynamics and Professor of Mathematics
https://www.justice.gov/epstein/files/DataSet%2010/EFTA02016026.pdf
link between chemical kinetics and when life takes over.
"Prelife morphs into life when replication occurs," Martin Novak asserted, Director of the
Program for Evolutionary Dynamics and Professor of Mathematics ... life," he explains, "and it's not clear whether metabolism
came first or replication. What is clear, is that replication sets evolution into full motion,
dramatically distinguishing life from prelife ... mechanism that allows for efficiency and
complexity to develop."
"Replication is the ultimate catalyst for life," Jeffrey Epstein adds, founder of The Jeffrey Epstein
Foundation. "The fittest molecules dominate quickly
https://www.justice.gov/epstein/files/DataSet%2010/EFTA02032283.pdf
EFTA01883636Set 10
2012-05-153p1,075w
when life takes over.
EFTA_R1_00297936
EFTA01883636
"Prelife morphs into life when replication occurs," Martin Novak asserted, Director of the Program for
Evolutionary Dynamics and Professor of Mathematics ... life," he explains, "and it's not clear whether metabolism came first or
replication. But replication sets evolution into full motion, dramatically distinguishing life from prelife.
It's the mechanism ... that allows for efficiency and complexity to develop."
"Replication is the catalyst for life," Jeffrey Epstein adds, founder of The Jeffrey Epstein Foundation.
"The fittest molecules dominate quickly, then
https://www.justice.gov/epstein/files/DataSet%2010/EFTA01883636.pdf
EFTA00659952Set 9
2012-05-163p828w
link
between chemical kinetics and when life takes over.
"Prelife morphs into life when replication occurs," Martin Novak asserted, Director of the Program for Evolutionary
Dynamics and Professor of Mathematics ... life," he
explains, "and it's not clear whether metabolism came first or replication. But replication sets evolution into full motion,
dramatically distinguishing life from prelife. It's the mechanism ... that allows for efficiency and complexity to develop."
"Replication is the catalyst for life," Jeffrey Epstein adds, founder of The Jeffrey Epstein Foundation. "The fittest
molecules dominate quickly, then
https://www.justice.gov/epstein/files/DataSet%209/EFTA00659952.pdf
link between chemical kinetics and when life takes over.
"Prelife morphs into life when replication occurs," Martin Novak asserted, Director of the
Program for Evolutionary Dynamics and Professor of Mathematics ... life," he explains, "and it's not clear whether
metabolism came first or replication. What is clear, is that replication sets evolution into full
motion, dramatically distinguishing life from prelife ... mechanism that allows for
efficiency and complexity to develop."
"Replication is the ultimate catalyst for life," Jeffrey Epstein adds, founder of The Jeffrey
Epstein Foundation. "The fittest molecules dominate quickly
https://www.justice.gov/epstein/files/DataSet%209/EFTA01105432.pdf
EFTA01183812Set 9
7p6,562w
able to spontaneously assemble into vesicles in
are beneficial even before the presence of replication or selection. aqueous conditions [23-25]. Alternatively, lipids could have
We argue that the ability ... molecules.
elements significantly. This in turn suggests that assembling com- After the onset of replication (on a molecular or cellular level),
plicated sets of functions at random ... even before
living organisms [13-15]. However, well-mixed populations of the emergence of replication (and evolution). sex could have
such molecules often stiffer from well-known pitfalls, including been
https://www.justice.gov/epstein/files/DataSet%209/EFTA01183812.pdf
EFTA01091492Set 9
22p5,709w
modeled by
subgame perfection and learning or evolutionary dynamics, as mod-
eled by the replicator dynamic. Using computer simulations, we
also show that it emerges with high frequency, even ... where
the population mixes between different strategies.
Consequently, we employ computer simulations of the replicator dynamic to explore
the evolutionary dynamics of the envelope game. The replicator dynamic ... population
is proportional to the fitness relative to that type's other strategies. Since replicator
dynamics cannot be solved in closed form, they must analyzed using computer simulations
seeded with
https://www.justice.gov/epstein/files/DataSet%209/EFTA01091492.pdf
EFTA01145243Set 9
42p22,663w
introducing an important extension of rewriting rules, namely, rewriting with replication, [60].
In such systems, the rules are of the form a (u1, tart)li(lz, tarz ... rules a (ui, tari),I < i < n,
without changing the language; th at is, replication makes a difference only in the halting case.
The replicated rewriting is important ... other operations which replicate partially or totally the contents of a membrane), membrane
creation (c ombined with the creation of exponentially many objects), and string replication.
Similar possibilities are offered
https://www.justice.gov/epstein/files/DataSet%209/EFTA01145243.pdf
EFTA01146514Set 9
54p20,630w
regression cooperation suggested by the correlation shown in Fig. 1. b, We replicate the
analyses. finding that forcing subjects to decide quickly promotes cooperation in a second
Additionally, we recruited ... study run in the physical laboratory with tenfold larger stakes = 211). We also
replicated our time-constraint experiment in the physical laboratory find that the time constraint has no significant ... need for more cognitively com-
We test this prediction on AMT with a replication of our conceptual plex economic and evolutionary models of cooperation, along the lines
priming experiment
https://www.justice.gov/epstein/files/DataSet%209/EFTA01146514.pdf