different WV strains in vitro, H2G is up to 400x more potent than acyclovir (ACV)
• H2G is approx. 250x-better substrate for VZV encoded thymidine kinase than ACV
• The intracellular ... Study showed a 10% decrease In pain duration with 750 mg BID, compared to acyclovir
EP8-348 EPB-348 M8-348 Acyclevfr
Parameter ... against placebo for both antiviral
(cutaneous) and pain endpoints
Previous clinical studies with Acyclovir, Valtrex and Famvir suggest that they may
have some impact on reducing pain & PHN
• The pain