EFTA02702876Set 11
2015-02-0214p12,563w
single male. We derive precise conditions for the invasion and stability of policing alleles. We And
Keywords: that the relatedness-based argument is not robust with respect to small changes ... observational evidence that find policing in singly mated species;
consider both dominant and recessive alleles affecting worker examples of species with single mating and worker policing are
behavior, but they ... Camponotusjlortdanus (Endler et
Ratnieks (1988, considers the invasion of a dominant allele for al., 2004), Aphaenogaster smythiesi (Wenseleers and Ratnieks,
policing. Using population genetics, he arrives at essentially the 200bh
https://www.justice.gov/epstein/files/DataSet%2011/EFTA02702876.pdf
EFTA01140242Set 9
2013-08-2714p12,142w
risk assessment and evaluate the limitations and barriers identified in an individual where the alleles are found in Human
for the adoption of this technology into medical practice. We Genome ... performed whole exome sequencing (WES) on 81 volunteers, and disease-causing mutations (DM). These alleles also were re-
for each volunteer, we requested personal medical histories, quired to be rare ... allele frequency in 6,500 exomes from
constructed a three-generation pedigree, and required their the National Heart, Lung, and Blood Institute (NHLBI) Exome
participation in a comprehensive educational program
https://www.justice.gov/epstein/files/DataSet%209/EFTA01140242.pdf
EFTA01205594Set 9
15p4,282w
endonuclease target sequence, resulting in the creation of a drive-resistant allele rather than the
EFTA01205595
46 desired duplication of the drive allele (Fig. lb). Far from an unlikely scenario ... population of diploid organisms and focus on a specific locus which has three alleles, the wild-
51 type (A), the gene drive (D), and a drive-resistant allele (R) which ... abstract the cellular-level drive dynamics, we assume that the wild-
53 type allele in an AD heterozygote is converted to a drive allele with probability
https://www.justice.gov/epstein/files/DataSet%209/EFTA01205594.pdf
EFTA00591446Set 9
15p4,282w
endonuclease target sequence, resulting in the creation of a drive-resistant allele rather than the
EFTA00591447
46 desired duplication of the drive allele (Fig. lb). Far from an unlikely scenario ... population of diploid organisms and focus on a specific locus which has three alleles, the wild-
51 type (A), the gene drive (D), and a drive-resistant allele (R) which ... abstract the cellular-level drive dynamics, we assume that the wild-
53 type allele in an AD heterozygote is converted to a drive allele with probability
https://www.justice.gov/epstein/files/DataSet%209/EFTA00591446.pdf
EFTA00315100Set 9
14p13,437w
findings into SSAGA (25-27). Of these, —14% (mean, 1530 ± 518 SD) had an allele fiequen-
cy that was sufficiently low to be a candidate for being causative ... uncommon disease (<1% allele frequency in 836 individuals sequenced d
at CMH) (42). Last, of these, —71% (mean, 1083 ± 240 SD) were also of
S
a functional class that ... three terms (table S3). Only E
RUNES variant annotation 16 known pathogenic variants had allele frequencies in dbSNP and the 2
CMH cumulative database that were consistent with uncommon
https://www.justice.gov/epstein/files/DataSet%209/EFTA00315100.pdf
EFTA01140307Set 9
2012-02-284p3,580w
carrier status, and rarer
charged ions has been the backbone of diagnosis, management, Duarte allele I (GALT N314D + L2I8L) pin of function muta-
and/or treatment for hundreds of inherited metabolic ... assist in clinical
samples postmortem. analysis. GET-Evidence prioritizes variants for review based on allele
To date, over 1,500 individuals have fully completed enrollment frequency, protein-predicted pathogenicity
https://www.justice.gov/epstein/files/DataSet%209/EFTA01140307.pdf