EFTA00292520Set 9
2014-07-1720p1,258w
Stem-Cell Gene Therapy
• Goal: Cure genetic blood diseases(e.g., Sickle Cell Anemia)
• Clinical stage: H2 2017 (1" trial, Leukemia with high-risk genetic
characteristics)
2. E-CEL Cellular Therapy ... Market Cancer Care Market
• Genetic diseases (e.g. Sickle Cell • 40% of adults will be
Anemia, Primary Immuno-Deficiency, diagnosed with cancer during
etc.) are responsible for a heavy their lifetimes5 ... Phase lb Trial
Phase 2 Trial
Pre-Clinical & (Leukemia with high-
IND (Sickle Cell Anemia)
risk genetic profile)
Done H2-2017 H 2-2019
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EFTA00292526
Clear
https://www.justice.gov/epstein/files/DataSet%209/EFTA00292520.pdf
EFTA00625099Set 9
30p10,397w
these patients have genetic disorders of
retinal phosphodiesterases);
• Patients with sickle cell or related anemias.
Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours ... patients who have conditions
which may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or
leukemia).
The safety and efficacy of combinations of VIAGRA with other treatments ... esophagitis, stomatitis,
dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis.
Hemic and Lymphatic: anemia and leukopenia.
Metabolic and Nutritional: thirst, edema, gout, unstable diabetes, hyperglycemia, peripheral
edema, hyperuricemia, hypoglycemic
https://www.justice.gov/epstein/files/DataSet%209/EFTA00625099.pdf
EFTA00625051Set 9
40p15,170w
menses:
• Increased menstrual cycle regularity
• Decreased blood loss and decreased incidence of iron-deficiency anemia
• Decreased incidence of dysmenorrhea
Effects related to inhibition of ovulation:
• Decreased incidence of functional ovarian ... important noncontraceptive health benefits.
These include less painful menstruation, less menstrual blood loss and anemia, fewer
pelvic infections, and fewer cancers of the ovary and the lining of the uterus ... Blood flow during menstruation may be lighter and less iron may be lost.
Therefore, anemia due to iron deficiency is less likely to occur
• Pain or other symptoms during menstruation
https://www.justice.gov/epstein/files/DataSet%209/EFTA00625051.pdf
EFTA00606146Set 9
2010-08-0912p14,739w
inallaleally or
fain& Mill nthsm. nhothlf obItTalt'a as Dommliol. Way. aatersnodelon pater or anemias end Witter recovely Won nth wrovr.ts may
be or finale; may tscome banal ... Arlirle 0 of dot ttaltOnn CornintectM Code. Any Co Vote,, dales, or controvala anemia Om lawanall er
flualleblelleas of any act. or exec's. dany MOM abcande2 any calparaL Including
https://www.justice.gov/epstein/files/DataSet%209/EFTA00606146.pdf