product is a 380-kd protein made up of 3,418 amino acids. Like BRCA1, BRCA2 is a tumor
suppressor gene whose mutations increased risk of breast, ovarian, and other ... RAD51 protein, a key component in homologous recombination and double-strand break
repair.
Pathogenic BRCA1 or BRCA2 mutations cause hereditary breast and ovarian cancer syndrome
(HBOC), and, to a lesser ... melanoma. The lifetime risk for these cancers in individuals with a mutation
in BRCA1 or BRCA2 is estimated to be:
The lifetime risk for these cancers in individuals with