EFTA01135800Set 9
6p1,835w
Possible pathogenic hits (see excel file):
1. BRCA2 c.8873_8874insAAGT 22): potential increase lifetime risk of breast cancer of
40-80% and ovarian cancer of 11-40%
2. BRCA2 c.1536delT ... consider testing female family members and be aware of potential
increased risk ofprostate cancer.
BRCA2 is a gene on 13q13.1 encoding a 10.4-kb transcript and composed of 27 exons ... protein made up of 3,418 amino acids. Like BRCA1, BRCA2 is a tumor
suppressor gene whose mutations increased risk of breast, ovarian, and other cancers through loss
of function
https://www.justice.gov/epstein/files/DataSet%209/EFTA01135800.pdf
EFTA01092332Set 9
2013-06-132p542w
therefore patentable.
Myriad Genetics, based in Utah, obtained broad patents on BRCA1 and BRCA2, genes linked to
a significant increase in the risk of breast and ovarian cancers in women ... patents gave the company the exclusive right
to isolate someone's BRCA1 and BRCA2 genes. Dr. Ostrer said after the court's ruling that the
price of the tests would
https://www.justice.gov/epstein/files/DataSet%209/EFTA01092332.pdf