EFTA01201684Set 9
2010-10-087p6,726w
Timing and heterogeneity of mutations associated with
drug resistance in metastatic cancers
Ivana Bozic'' and Martin A. Nowa ka'bi
'Program for Evolutionary Dynamics, Department of Mathematics, and °Department ... show that this ordering is often
2 of 5 I www.poes.cregfCgilda/10.107342nat.1412075111 Bozic and Nowak
EFTA01201685
violated. In 31% of lesions, the first successful subclone is smaller that the ratio ... time of
appearance. Parameter values for all simulations: b =0.25, d=0.181, u=42.104.
Bozic and Nowak PNAS Batty Edition I 3 of 5
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Table 1. Comparison of predicted
https://www.justice.gov/epstein/files/DataSet%209/EFTA01201684.pdf
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Timing and heterogeneity of mutations
associated with drug-resistance in metastatic
cancers
Ivana Bozic • •1 and Martin A. Nowak' 1 .1
• Progam for Evolutionary Dynamics. Department of Mathematics ... colorectal cancer. Nature486:532-536.
BRAF V600E mutation. NEngIJ Med 364:2507.2516. 15. Bozic 1. et al. (2013) Evolutionary dynamics al cancer In response to targeted com-
7. IMemondo ... Bellegowda C, el at (2014) Delectlon of circulating tumor DNA in early- and
22. Bozic I, Allen 8, Now* MA (2012) Dynamics of targeted cancer therapy. Dana, MOI late-stage
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crypt and in
colorectal cancer. Proc. Nan Aced Sri. USA 104.4008-4013 (2007).
8. Bozic. Let Accumulation of driver and passenger mutations during tumor 24. Talmadge.J. E. & I.J.AACR Centennial Series ... carcinoma and extended benefit from mTOR inhibitor therapy. C& CancevRes
42. Reiter.J. G.. Bozic. LAllen. B, Chattelee, K. & Nowak. M.A. The effect of one 20, 1955-1964 (2014).
additional ... Hoehme. S.& Block. M. On the role of physics in the growth and 95. Bozic. I. Mat Evolutionary dynamics of cancer in response to targeted
pattem formation of multi-cellular
https://www.justice.gov/epstein/files/DataSet%209/EFTA00603737.pdf
Harvard University,
under the direction of Martin Nowak and mathematics graduate student Ivan Bozic PhD, has
shown that only a small percentage of a tumor's mutations drive tumor growth ... based on mathematic models of how cancer cells evolve within patients' tumors.
What Bozic and researchers found, was that most solid tumors contain 40 to 100 mutations in coding
genes
https://www.justice.gov/epstein/files/DataSet%209/EFTA01131064.pdf
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Evolutionary set theory — Corina Tarnita
Driver and passenger mutations in cancer progression — Ivan Bozic, Tibor Antal, Martin Nowak, Bert Vogelstein
Indirect Speech — Martin Nowak [with Steven Pinker (Psychology)]
Facilitated Evolution ... Clonal Expansions: Discrete and Continuous Time Models — Martin Nowak, Tibor Antal and
Ivana Bozic [with Hisashi Ohtsuki (Tokyo Institute of Technology) and Bert Vogelstein [Johns Hopkins
University])
A Theoretical Investigation
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EFTA01116328Set 9
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kinds. In 2012,
Nowak and two postdoctoral students, Benjamin Allen and Ivana Bozic, developed the first
mathematical model of how human colon-cancer cells evolve and how they become immune ... those without. The same
tailored approach is underway for other cancers.
In 2010, Ivana Bozic and Martin Nowak co-authored a mathematical study that showed that most
solid tumors contain
https://www.justice.gov/epstein/files/DataSet%209/EFTA01116328.pdf
EFTA01961023Set 10
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kinds. In
2012, Nowak and two postdoctoral students, Benjamin Allen and Ivana Bozic, developed the first
EFTA_R1_00435627
EFTA01961024
mathematical model of how human colon-cancer cells evolve ... those without. The same tailored approach is
underway for other cancers.
In 2010, Ivana Bozic and Martin Nowak co-authored a mathematical study that showed that most
solid tumors contain
https://www.justice.gov/epstein/files/DataSet%2010/EFTA01961023.pdf
EFTA01964817Set 10
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kinds. In 2012,
Nowak and two postdoctoral students, Benjamin Allen and Nana Bozic, developed the first
mathematical model of how human colon-cancer cells evolve and how they become immune ... those without. The same tailored approach is
underway for other cancers.
In 2010, Ivana Bozic and Martin Nowak co-authored a mathematical study that showed that most
solid tumors contain
https://www.justice.gov/epstein/files/DataSet%2010/EFTA01964817.pdf
EFTA01966271Set 10
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colon cancer. In 2012, Martin Nowak and
post-doctoral students, Benjamin Allen and Ivana Bozic, developed the first mathematical model of how
human colon cancer cells evolve and specifically ... without. The same tailored approach is underway for other
cancer types.
In 2010, Nana Bozic and Martin Nowak co-authored a pivotal mathematical study that showed that most
solid tumors
https://www.justice.gov/epstein/files/DataSet%2010/EFTA01966271.pdf
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colon cancer. In 2012, Martin Nowak and
post-doctoral students, Benjamin Allen and Ivana Bozic, developed the first mathematical model of how
human colon cancer cells evolve and specifically ... without. The same tailored approach is underway for other
cancer types.
In 2010, Ivana Bozic and Martin Nowak co-authored a pivotal mathematical study that showed that most
solid tumors
https://www.justice.gov/epstein/files/DataSet%209/EFTA01071423.pdf
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kinds. In
2012, Nowak and two postdoctoral students, Benjamin Allen and Ivana Bozic, developed the
first mathematical model of how human colon-cancer cells evolve and how they become immune ... those without. The same
tailored approach is underway for other cancers.
In 2010, Ivana Bozic and Martin Nowak co-authored a mathematical study that showed that most
solid tumors contain
https://www.justice.gov/epstein/files/DataSet%209/EFTA01116320.pdf
EFTA00589683Set 9
5p1,569w
kinds. In
2012, Nowak and two postdoctoral students, Benjamin Allen and Ivana Bozic, developed the
first mathematical model of how human colon-cancer cells evolve and how they become immune ... those without. The same
tailored approach is underway for other cancers.
In 2010, Ivana Bozic and Martin Nowak co-authored a mathematical study that showed that most
solid tumors contain
https://www.justice.gov/epstein/files/DataSet%209/EFTA00589683.pdf
EFTA00416163Set 9
2012-04-103p649w
Peter >, "Fu,
Feng" "Lieberman, Erez" "Michel, Jean-
Baptiste" , "Pfeiffer, Thomas" , "Rand,
David" , Corina Tamita >, "Bozic, Ivana"
"Hill, Alison" >, "Rosenbloom, Daniel"
>, "Hauser, Oliver >, "Chung, Hattie"
>, Tibor Antal >, Tore Ellingsen
>. "Huang
https://www.justice.gov/epstein/files/DataSet%209/EFTA00416163.pdf
EFTA00417489Set 9
2012-03-203p796w
Peter"
"Fu, Feng" < "Lieberman, Erez" < , "Michel,
Jean-Baptiste" < >, "Pfeiffer, Thomas"
"Rand, David" < , Corina Tamita < >, "Bozic,
Ivana" >, "Hill, Alison" < "Rosenbloom, Daniel"
>, "Hauser, Oliver" < >, "Chung, Hattie"
>, Tibor Antal < >, Tore Ellingsen
>, "Huang
https://www.justice.gov/epstein/files/DataSet%209/EFTA00417489.pdf
EFTA00415809Set 9
2012-04-104p1,148w
Blake, P
"Fu, Feng" "Lieberman, Erez"
"Michel, Jean-Batiste" "Pfe
>, "Rand, David" < orina Tarnita
>, "Bozic, Ivana" < "Hill, Alison"
"Rosenbloom, Daniel" "Hauser,
, "Chun. Hattie" Tibor Antal
Tore Ellingsen , "Huang, May
Brian
https://www.justice.gov/epstein/files/DataSet%209/EFTA00415809.pdf
EFTA02339895Set 11
2014-10-152p205w
Nowak, Martin" <martin=nowak@harvard.edu <mailto:martin_nowak@harvard.edu», Ivana Bozic
<ibozic@math.harvard.edu <mailto:ibozic@math.h=rvard.edu», Ben Allen <benjcallen@gmail.com>
Dear Martin, Ivana, Ben,
we just put online this paper on the number
https://www.justice.gov/epstein/files/DataSet%2011/EFTA02339895.pdf