EFTA02295528Set 11
49p3,041w
EFTA02295548
Maji Therapeutics
• High failure rate of bypass grafts
• -45 % at 12 mo. - CABG
• Novel, ex vivo HSV-1 therapy
• Strong value proposition, very low COGS
• 850,000+ annual procedures ... they are converted from
veins to arteries .
■ Why Is It Important?
46.3% of all CABG procedures will experience at least one vein graft failure within
the first year of surgery ... principally due to neointimal hyperplasia. CABG patients
who experience vein graft failure have a dramatically higher incidence of
myocardial infarction, death, revascularizations and hospital readmissions.
Reducing vein graft failure
https://www.justice.gov/epstein/files/DataSet%2011/EFTA02295528.pdf
EFTA00506107Set 9
49p3,212w
LLC7
EFTA00506127
Maji Therapeutics
• High failure rate of bypass grafts
• —45 % at 12 mo. — CABG
• Novel, ex vivo HSV-1 therapy
• Strong value proposition, very low COGS
• 850,000+ annual ... they are converted from
veins to arteries .
■ Why Is It Important?
46.3% of all CABG procedures will experience at least one vein graft failure within
the first year of surgery ... principally due to neointimal hyperplasia. CABG patients
who experience _ vein
. graft failure have a dramatically higher
. . incidence
. . . of
myocardial infarction, death, revascularizations and hospital readmissions.
Reducing vein graft failure
https://www.justice.gov/epstein/files/DataSet%209/EFTA00506107.pdf
EFTA01141522Set 9
2013-11-1033p13,378w
seen) is at the bottom.
Coronary artery bypass surgery, also coronary artery bypass graft (CABG, pronounced "cabbage')
surgery, and colloquially heart bypass or bypass surgery is a surgical procedure performed ... heart stopped, necessitating the usage of cardiopulmonary
bypass; techniques are available to perform CABG on a beating heart, so-called "off-pump" surgery.
giFile:Blausen 0466 Heart Bypass Surgery.png
Illustration ... used for the bypass.
EFTA01141536
Single Double Triple Quadruple
Coronary Artery Bypass Graft (CABG)
Illustration depicting single, double, triple, and quadruple bypass
Russian cardiac surgeon, Dr. Vasilii Kolesov, performed
https://www.justice.gov/epstein/files/DataSet%209/EFTA01141522.pdf
EFTA00506157Set 9
46p3,296w
CAPIIAL
EFTA00506180
Maji Therapeutics
• High failure rate of bypass grafts
• —45 % at 12 mo. — CABG
■ Novel, ex vivo HSV-1 therapy
• Strong value proposition, very low COGS
• 900,000+ annual ... cost to the patient.
DACAR! C API TAL LLC
EFTA00506182
Maji Therapeutics
■ Investment Thesis
• CABG failure is "an unmet medical need".
• We have the intellectual property.
• We have compelling preclinical
https://www.justice.gov/epstein/files/DataSet%209/EFTA00506157.pdf
EFTA00625099Set 9
30p10,397w
hypertension, other cardiac disease, peripheral vascular
disease, diabetes mellitus, depression, coronary artery bypass graft (CABG), radical
prostatectomy, transurethral resection of the prostate (TURF) and spinal cord injury, and in
patients
https://www.justice.gov/epstein/files/DataSet%209/EFTA00625099.pdf