EFTA01110707Set 9
22p7,189w
Neurosurgery
JEFFERSON MEDICAL COLLEGE, Philadelphia, PA, USA
EFTA01110707
LEONE, Paola
1998-2001 Associate Director
CNS Gene Therapy Center
JEFFERSON MEDICAL COLLEGE, Philadelphia, PA, USA
2002-2007 Associate Professor
Department ... Japan
2004 Myelin Project Annual Meeting, Aquiterme, Italy
2004 NAA Symposium, Bethesda, MD
2004 CNS Foundation, Tarrytown, NY
2005 National Tay Sachs & Allied Disorders, Annual Conference,New Orleans
2005 American ... Leone, P., Janson, C.G., McPhee, S.J., During, M.J. (1999) Global CNS Gene Transfer for
Childhood Neurogenetic Enzyme Deficiency: Canavan Disease. Current Opinions in
Molecular Therapeutics
https://www.justice.gov/epstein/files/DataSet%209/EFTA01110707.pdf
EFTA01079016Set 9
2015-12-3169p22,497w
December 2015
I 2013 multiples include the following firms: APAM, BPFH, CLMS, CNS, DHIL, EV, GBONS, PZN, SAMG, VRTS, WDR and WHG. 2014 multiples include the
following firms: APAM, BPFH ... CLMS, CNS, DHIL, EV, GBL, JNS, PZN, SAMG, VRTS, WDR and WHG. 2015 multiples include APAM, BPFH, CLMS, CNS, OHIL, EV,
GSL, INS, PZN, SAMG, VRTS, WDR and WHG.
Berkshire ... rates.
Index includes AMG, APAM (as of 3/13), ART (3/11through 12/12), BEN, BLK, CLMS, CNS, EPHC (3/11
through 11/12), EV, FII, GBL, GROW (3/11through 4/12
https://www.justice.gov/epstein/files/DataSet%209/EFTA01079016.pdf
EFTA00799222Set 9
73p4,210w
treatment
options in drug discovery and development
• We have privileged access to global CNS pharma experts through our Scientific Advisory Board
• Provide advice, share knowledge and offer insights on different ... Correlate
of Cognitive Decline
Clinical Disease Stage
Sperling et al., 2011
EFTA00799243
How are CNS
Synapses Eliminated ?
oiigodenerocyte
Neuron
EFTA00799244
Immune System: Complement Proteins
are 'Eat me' signals that ... EFTA00799248
Development/Plasticity/Repair J J Neuroscience (2013)
A Dramatic Increase of Clq Protein in the CNS during
Normal Aging
Alexander H. Stephan,' Daniel V. Madison,2 Jose Maria Mateos,3 Deborah
https://www.justice.gov/epstein/files/DataSet%209/EFTA00799222.pdf
EFTA00296820Set 9
17p6,870w
NICU)
B. Autonomic-neurophysiologic (e.g., number of hypotensive episodes)
C. Medical (e.g., exposure to CNS-active drugs)
D. Behavioral (e.g., exploratory motor behaviors)
EFTA00296826
Tramo GRANT PROPOSAL: The Jeffrey Epstein ... mechanical
ventilation and tube feedings, sleep-wake cycles, exposure to sedatives and other CNS-active drugs,
and weight gain — will be monitored daily. Salivary cortisol and IgA will be analyzed ... from the NICU, and collection of data about medical
complications, exposure to drugs with CNS activity, weight gain, length of acute-care hospital stay,
and total acute-care costs will
https://www.justice.gov/epstein/files/DataSet%209/EFTA00296820.pdf
EFTA01127977Set 9
2014-09-249p2,510w
enormous success in the identification of novel therapeuti
c targets for a variety of CNS
disorders—including Parkinson's disease, schizophrenia,
and age-related cognitive
decline —which have already ... been employed by the Greengard and Heintz laboratories for comparative
analysis of nearly 100 CNS cell types, including many of those that comprise the CSTC circuitry relevant to
OCD. These ... studies have resulted in identification of novel therapeutic targets for a variety of CNS
disorders—including Parkinson's disease, schizophrenia, and age-related cognitive decline—that have
already
https://www.justice.gov/epstein/files/DataSet%209/EFTA01127977.pdf
EFTA01178505Set 9
4p2,741w
case of tetanus, utilize retro- Relevant human data
grade signaling to the CNS. Given the well charac-
There are no published clinical trials or even case
terized pathogenicity of these ... tetanus toxin, can be dietary fiber intake, and decreased physical activity
transported to the CNS despite an intact blood- (22). However, a study using radio-opaque markers
brain barrier ... controls even if they did not complain of
in a retrograde fashion to the CNS, and thus has GI symptoms; this abnormal colonic motility did not
been studied
https://www.justice.gov/epstein/files/DataSet%209/EFTA01178505.pdf
EFTA00707641Set 9
2017-09-1024p6,911w
cranial and/or spinal nerves,and
transporting the therapeutic
peripherally through the nerves into
the CNS.
Publication number WO 2005021065 A3
Year 2005
Title Use of particulate agents
Abstract A novel ... intranasal route.
Neurological diseases and conditions
are associated with reduced brain
insulin signaling (i.e., CNS insulin
insensitivity), reduced dopaminergic
signaling, reduced serotonergic
signaling, reduced cholinergic
signaling, or reduced GABAergic
signaling ... insomnia, or
EFTA00707659
anxiety. Neurological diseases also
include cancers of the central nervous
system (CNS).
Publication number US 20140100282 Al
Year 2014
Title Method and applications of peptide-
mediated mitochondrial
https://www.justice.gov/epstein/files/DataSet%209/EFTA00707641.pdf
EFTA02683561Set 11
2014-09-249p2,522w
with
enormous success in the identification of novel therapeutic
targets for a variety of CNS
disorders—including Parkinson's disease, schizophrenia,
and age-related cognitive
decline —which have already ... been employed by the Greengard and Heintz laboratories for comparative
analysis of nearly 100 CNS cell types, including many of those that comprise the CSTC circuitry relevant to
OCD. These ... studies have resulted in identification of novel therapeutic targets for a variety of CNS
disorders—including Parkinson's disease, schizophrenia, and age-related cognitive decline—that have
already
https://www.justice.gov/epstein/files/DataSet%2011/EFTA02683561.pdf
EFTA01146437Set 9
2012-08-2332p8,298w
Institute for Brain Science
9:30 AM Mapping Gene Expression and Connections in the CNS:
Tools and Data from the Allen Institute for Brain
Science
Allan Jones, PhD, Allen Institute ... Cracking the Neural Code 11
EFTA01146447
ABSTRACTS
Mapping Gene Expression and Connections in the CNS: Tools and
Data from the Allen Institute for Brain Science
Allan Jones, PhD, Allen Institute
https://www.justice.gov/epstein/files/DataSet%209/EFTA01146437.pdf
EFTA00593632Set 9
2015-04-0112p7,332w
result
investors should be aware that the firm may have a conflict
CNS Monitoring fee expired in 4Q, drops to zero in 1Q: this drives a 29% of interest that ... shares near-term. While it's possible none could sell, history suggests partial selling.
CNS Monitoring fee expires in 4Q14, drops to zero in 1Q15: We flag as a headline
https://www.justice.gov/epstein/files/DataSet%209/EFTA00593632.pdf