Obsessive-Compulsive and
Comorbid Disorders
Molecular dissection of the cortico-striatal-thalamo-cortical (CSTC) circuits
controlling obsessive compulsive, depressive, and anxious behaviors in mammals
September 2014
Paul Greengard, Ph.D ... these circuits can have a positive
therapeutic effect in OCD. Additional support for the CSTC model has come from recent rodent studies of
OCD, where it has been demonstrated that ... artificial stimulation in CSTC pathways can elicit persistent
OCD-like behaviors, and that cortico-striatal synaptic defects cause similarly aberrant behaviors.
Taken together, the available clinical and experimental data allow