EFTA00625099Set 9
30p10,397w
potent cytochrome P450 3A4 inhibitors (e.g., erythromycin, ketoconazole,
itraconazole) as well as the nonspecific CYP inhibitor, cimetidine, is associated with increased
plasma levels of sildenafil (see DOSAGE AND ADMINISTRATION). Both ... VIAGRA
In vitro studies: Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP)
isoforms 3A4 (major route) and 2C9 (minor route). Therefore, inhibitors of these isoenzymes
14
EFTA00625112 ... these isoenzymes may increase sildenafil
clearance.
In vivo studies: Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increase in
plasma sildenafil concentrations when coadministered with VIAGRA
https://www.justice.gov/epstein/files/DataSet%209/EFTA00625099.pdf
EFTA00310887Set 9
2011-12-19103p24,458w
Mexico's choice of law
provisions.
Dated: December lb , 2011.
ASSIGNOR: ASSIGNEE:
CYP INC.,
a orporation
By
JEFFREY EPSTEIN, Trustee of Jeftey Epstein, President
the Zorro Trust uta dated
March
https://www.justice.gov/epstein/files/DataSet%209/EFTA00310887.pdf