EFTA00620069Set 9
26p10,915w
asking at this point, "What about drinking red
wine?" or "What about caloric restriction?"
After surveying the literature addressing this question, I believe the following statements are
accurate ... when repeatedly tested in controlled
trials. In other words, save your money.
3. Caloric restriction (CR) is probably the greatest action you can take to impact
longevity (shy of choosing ... mammalian target of rapamycin (mTOR). I'll
explain why.
A brief word on caloric restriction and mTOR inhibition
Caloric restriction
Though not seen uniformly across all species (e.g., significant longevity
https://www.justice.gov/epstein/files/DataSet%209/EFTA00620069.pdf
EFTA01045495Set 9
2018-05-2936p8,101w
down-
regulated when glucose availability is reduced or ketogenesis is increased40. Similar to
caloric restriction, mTOR inhibition can preserve brain metabolism with ageil,
potentially due to the shift from glucose ... EFTA01045514
■ CAS
■ Article
■ PubMed
■ Google Scholar
23.
Parikh, I. et al. Caloric restriction preserves memory and reduces anxiety of aging mice
with early enhancement of neurovascular functions. Aging ... Scholar
41.
Lin, A. L., Coman, D., Jiang, L., Rothman, D. L. & Hyder, F. Caloric restriction
impedes age-related decline of mitochondrial function and neuronal activity. J Cereb
Blood Flow
https://www.justice.gov/epstein/files/DataSet%209/EFTA01045495.pdf
EFTA01691125Set 10
100p39,113w
ALPLIA NFLIWITICROYAStM,
1544
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l ift.1644RJRCOW, NO IA114414.0lib /v. Al
244/4r2005 ... InItialion Ounitlim
Customer PITI Data Tame (SIC) Type FOIWairded 911 International Calor / Calla P771 Originating Cell Site Terminating Ca Site
MFL156211UWELLYGIN. NFL1502R/LViELLNOTN.
28-M•22006 a' PM 0 Whom
https://www.justice.gov/epstein/files/DataSet%2010/EFTA01691125.pdf