Epstein Files Search

EFTA02295528Set 11

49p3,041w

CAPITAL LLC EFTA_R1_01138811 EFTA02295537 EFTA_R1_01138812 EFTA02295538 Normal Vein Structure Lumen Endothelial cells Intima ,> Media Adventitic DACART CAPITAL LLC EFTA_R1_01138813 EFTA02295539 Injury to the Vessel ... smooth muscle cell proliferation 41•11. •MP ONO C 41111. OM* dEP, • Lumen Endothelial cells Intim° Growth factors, ctt(Npese [D.L-S P,FIT CAPITAL LLC EFTA_R1_01138815 EFTA02295541 Mechanism ... EFTA_R1_01138816 EFTA02295542 SMC migration and neointimal lesion development and graft failure Endothelial cells DAC ART CAPITAL LLC EFTA_R1_01138817 EFTA02295543 Delivery of Virus mar, WP C Lumen

https://www.justice.gov/epstein/files/DataSet%2011/EFTA02295528.pdf

EFTA00292520Set 9

2014-07-1720p1,258w

ANGIOCRINE BIOSCI ENCE Investor Update May 4th 2017 OO Nig9FRPA EFTA00292520 Fact: Endothelial Cells Instruct Stem Cells Endothelial Cells --- Angiocrine Factors Organ-Specific Stem Cells Signaling proteins ... regenerate MA19$:A!Ng 2 EFTA00292521 Uniquely Angiocrine Bioscience E-CELTM Injectable engineered human endothelial cells that can orchestrate regeneration of vital organs 4.J-CELTM Create your own stem ... cells from your own endothelial cells obtained via skin or fat samples No other company has technologies like ours ANGOGUNE EFTA00292522 Rapid Progress Over the Last Year 1) Awarded

https://www.justice.gov/epstein/files/DataSet%209/EFTA00292520.pdf

EFTA00506157Set 9

46p3,296w

DACAR I CAPI TAL LLC:. EFTA00506170 Normal Vein Structure Lumen Endothelial cells Intima IMbillil.0 ________4..._______ <---- 41=1. Media -",C-. V Adventitia DIACAR C API JAL LLC.L' EFTA00506171 Injury ... Vessel During Surgery _ OECD csakim --,- Qom. _ QM. Oara, Endothelial cells Intima Elastic < —> Media 4am. (m. 411110 amino Fibroblasts, fat cells Adventitia DACART CAP' IAL LLC EFTA00506172 Gro h factors, cytokines ... IIMM. ( ---- eztr> ewe> — 41MED —o -...—_412ZC> 411M2 0 00 0 0 0 00 Lumen Endothelial cells Intima Growth factors, cytokines 0 0 0 00 0 0 00 Elasticei

https://www.justice.gov/epstein/files/DataSet%209/EFTA00506157.pdf

EFTA00506107Set 9

49p3,212w

EFTA00506117 Normal Vein Structure -5 4M. ••=.• a•In. aNIMP ••=i• aNIMP Lumen Endothelial cells Intima E c aNIMP MIN• 711.• ,<_•■••• •■•• •111.• a<- Media 110 .Mi• aNIMP MIND laminae Pratm Adventitia ... ilINIP __________4i ----- a <- CIMP ,.> C., °o o 0 0 o o o Lumen Endothelial cells Intima Growth factors, cytokines 0 0 0 0 00 00 Elastic: 4=D laminc: 4IMMID ... Neointimal Thickening Medial SMC proliferation () 0 0 0 0 0 0 0 Lumen Endothelial cells Intima Growth factors, cit6b%-- oc) 00 la IMP Fibroblasts, fat cells, interstitial Adventitia IDACART

https://www.justice.gov/epstein/files/DataSet%209/EFTA00506107.pdf

EFTA00327843Set 9

2016-03-153p700w

accomplished by our proprietary E-CEL Technology—a series of genetically-modified human endothelial cells. E-CEL Technology is potentially applicable to every tissue/organ in the body. Recently, we were ... concept in non-human primates for allogeneic E-CEL UVEC (human umbilical vein endothelial cells) applicable to advancing gene therapy in multiple inherited diseases. • Achieved positive pre-clinical proof ... concept in murine (mouse) model of COPD using E-CEL PEC (Pulmonary Endothelial Cells). EFTA00327843 • Achieved positive pre-clinical proof-of-concept in murine (mouse) model of tendon reconstructing using

https://www.justice.gov/epstein/files/DataSet%209/EFTA00327843.pdf

EFTA00661247Set 9

2011-11-083p3,128w

shown benefit When kcally administered to tumors. This adjuvant is known to promote inftammatiert endothelial injury and apoptosis. a addition to being cytotoxic 10 cancer cells and generally harmful ... apoputic and necrotic cell death) as well as vascular mechanisms of idiocy related to endothelial cell activation and intiammation. Tftfta may enhance cryosurgical lesion in Avol83-35). Chao(36) examined ... Ruegg C. Yiknaz A. Bieler G. et al. Evidence for the invOlvernertl of endothelial cell irtegrin alphaVbeta3 in the &eruption of the tumor vasculahre induced by TNF and IFN-garnnia

https://www.justice.gov/epstein/files/DataSet%209/EFTA00661247.pdf

EFTA00620069Set 9

26p10,915w

penetrate the tight junctions of the endothelium and make their way into the sub-endothelial space (the zone underneath the endothelial later of the artery). Once there, a subset ... passage of time is the crucial risk for cardiovascular disease is because of continuous endothelial exposure to apoB. Hence, to delay death as long as possible due to CHD/CVD

https://www.justice.gov/epstein/files/DataSet%209/EFTA00620069.pdf

EFTA01092032Set 9

25p12,760w

Court ADRCs are a heterogeneous or mixed population of cells including adult stem cells, endothelial progenitor cells, leukocytes, endothelial cells, and vascular smooth muscle cells. Cytori believes this mixed population ... Exhibit 13. Heterogeneous cells in ADRCs Vascular Smooth Tissue Muscle Cells Macrophage 9% 3% Endothelial Cells - 7% White Wood CD34./CDS1 Cells Stem Cells 22% 37% 2% Source: Cytori Cytori

https://www.justice.gov/epstein/files/DataSet%209/EFTA01092032.pdf

EFTA01045495Set 9

2018-05-2936p8,101w

These neurovascular enhancements were associated with reduced mechanistic target of rapamycin (mTOR) and increased endothelial nitric oxide synthase (eNOS) protein expressions. KD also increased the relative abundance of putatively beneficial ... reported that inhibiting mechanistic target of rapamycin (mTOR) signaling increases neurovascular function by activating endothelial nitric oxide synthase (eNOS)nn. In this study, we also found that mTOR protein expression ... group, "'Pp< 0.001. mTOR: mechanistic target of Rapamycin; P-gp: P-glycoprotein; eNOS; endothelial nitric oxide synthase. Full size image Ketogenic diet alters gut microbial diversity and increases beneficial microbiota

https://www.justice.gov/epstein/files/DataSet%209/EFTA01045495.pdf

EFTA00308035Set 9

2005-01-0111p7,546w

combination group demonstrated Olmarker and others (1993) used autologous NP edema, endothelial and Schwann cell hypertrophy, harvested from the intervertebral disc in hogs and demyelinization, and widespread myelin abnormali- placed ... group, there was conduction velocities were recorded. The mean nerve edema, endothelial cell activation, and myelin disrup- conduction velocities in the live fibroblasts and condi- tion. The results of this ... expressed in herniated discs, particularly in group showed no apparent morphological changes. chondrocytes, endothelial cells, and in the granulation The results suggest that a small production of TNF-a tissue

https://www.justice.gov/epstein/files/DataSet%209/EFTA00308035.pdf

EFTA01741615Set 10

2011-11-087p3,030w

shown benefit when locally administered to tumors. This adjuvant is known to promote inflammation, endothelial injury, and apoptosis, in addition to being cytotoide to cancer cells and generally harmful ... apoptotic and necrotic cell death) as well as vascular mechanisms of injury related to endothelial cell activation and inflammation, TNF-a may enhance cryosurgical lesion in vtvo[33-351. Chaol36

https://www.justice.gov/epstein/files/DataSet%2010/EFTA01741615.pdf

EFTA01850362Set 10

2011-11-087p3,025w

shown benefit when locally administered to tumors. This adjuvant is known to promote inflammation, endothelial injury, and apoptosis, in addition to being cytotoide to cancer cells and generally harmful ... apoptotic and necrotic cell death) as well as vascular mechanisms of injury related to endothelial cell activation and inflammation, TNF-a may enhance cryosurgical lesion in vtvo[33-351. Chaol36

https://www.justice.gov/epstein/files/DataSet%2010/EFTA01850362.pdf

EFTA02031879Set 10

2011-11-087p3,029w

shown benefit when locally administered to tumors. This adjuvant is known to promote inflammation, endothelial injury, and apoptosis, in addition to being cytotoide to cancer cells and generally harmful ... apoptotic and necrotic cell death) as well as vascular mechanisms of injury related to endothelial cell activation and inflammation, TNF-a may enhance cryosurgical lesion in vtvo[33-351. Chaol36

https://www.justice.gov/epstein/files/DataSet%2010/EFTA02031879.pdf

EFTA01141522Set 9

2013-11-1033p13,378w

blood thinners. "We could coat a stent with our peptide, attracting endothelial stem cells to form a film on the surface of the stent. These endothelial cells on the stent

https://www.justice.gov/epstein/files/DataSet%209/EFTA01141522.pdf

EFTA00566738Set 9

2016-07-1622p8,298w

induced headache is a vascular headache caused mainly by nitrate monoxide (62). Histamine releases endothelial nitrate monoxide upon stimulation of H I R, which is also expressed in the large ... sexual steroids In the female genital tract, histamine is mainly produced by mast cells, endothelial cells, and epithelial cells in the uterus and ovaries. Histamine-intolerant women often suffer from

https://www.justice.gov/epstein/files/DataSet%209/EFTA00566738.pdf

EFTA00661250Set 9

2011-11-084p3,024w

shown benefit :Men locally administered to timers. This arluvant is known to promote inflarnmatice. endothelial injury and apoceteis. in addition to being cytotoxic to cancer cells and generally harmful ... apoptotic and necrotic cell death) as well as vascular mechanisms of injury rented to endothelial cell activation and inflammation. TNFo may entiance coos:pion lesion in vivol33-35). Chac66] examined

https://www.justice.gov/epstein/files/DataSet%209/EFTA00661250.pdf

EFTA00450648Set 9

2017-05-072p460w

combination of cord blood stem cells cultured and expanded with our proprietary human engineered endothelial (E-CEL) cells. First patients to treat, as suggested by the FDA, is in patients ... other research programs including our 2nd proprietary technology, Psi-CEL, which can convert endothelial cells to blood stem cells, in animals. We consider this new program not only to have

https://www.justice.gov/epstein/files/DataSet%209/EFTA00450648.pdf

EFTA01046722Set 9

2017-05-082p685w

combination of cord blood stem cells cultured and expanded with our proprietary human engineered endothelial (E-CEL) cells. First patients to treat, as suggested by the FDA, is in patients ... other research programs including our 2nd proprietary technology, Psi-CEL, which can convert endothelial cells to blood stem cells, in animals. We consider this new program not only to have

https://www.justice.gov/epstein/files/DataSet%209/EFTA01046722.pdf

EFTA01172795Set 9

2p1,095w

dysfunction including aging, aplastic anemia, cancer, dyskeratosis congenita, Duchenne muscular dystrophy, hypertension, atherosclerosis and endothelial cell death. Critically, short telomeres also destabilize adult stem cell differentiation, essential for tissue regeneration ... volume in cell culture tissue regeneration. Some adult stem cells for example, such as Endothelial progenitor cells, are difficult to harvest due to their low volume. By rapidly increasing

https://www.justice.gov/epstein/files/DataSet%209/EFTA01172795.pdf

EFTA02444651Set 11

2008-11-0638p10,506w

protein terminated) and cell-unfriendly (polyethylene-glycol terminated) SAMs can be used to pattern endothelial cells on surfaces and to even force these cells to take on specific shapes (Figure

https://www.justice.gov/epstein/files/DataSet%2011/EFTA02444651.pdf