fully characterized. Here we show that
the induction of mitophagy by the mitochondrial uncoupler
FCCP is independent of the effect of mitochondrial membrane
potential but dependent on acidification ... cytosol by FCCP.
The ionophore nigericin also reduces cytosolic pH and induces
PINK1/PARKIN-dependent and -independent mitophagy. The
increase of intracellular pH with monensin suppresses the
effects of FCCP and nigericin