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company needed a blockbuster that would replace and surpass its original antipsychotic drug, Haldol, which had gone on sale in the late 1960s. Haldol had been invented in the laboratories ... Johnson away from medical supplies and toward the blossoming, high-margin prescription drug business. Haldol and competitors, such as Thorazine, were considered "first-generation" antipsychotics—drugs that could treat symptoms ... portion of the one percent of Americans having the most severe psychotic disorders. But