Epstein Files Search

EFTA00447987Set 9

2017-03-244p1,054w

From: Lesley Groff To: Jeffrey Epstein <jeevacation@gmail.com> Subject: Fwd: FOURIER: Significant LDL Reduction with Evolocumab Date: Fri, 24 Mar 2017 11:18:31 +0000 Begin forwarded message: From: Subject ... FOURIER: Significant LDL Reduction with Evolocumab Date: March 24, 2017 at 7:17:36 AM EDT To: Lesley Groff < Lesley please forward to Jeffrey rs Rony Shimony, M.D. F.A.C.C. Associate ... Date: March 24, 2017 at 7:06:06 AM EDT To: Subject: FOURIER: Significant LDL Reduction with Evolocumab Reply-To: Cardiology Alert < EFTA00447987 Entail not displaying coirectly?View

https://www.justice.gov/epstein/files/DataSet%209/EFTA00447987.pdf

EFTA00447984Set 9

2017-03-243p1,043w

From: Lesley Groff To: "Dr. Rony + Catherine Shimony" Subject: Re: FOURIER: Significant LDL Reduction with Evolocumab Date: Fri, 24 Mar 2017 11:18:21 +0000 will do..thanks ... Date: March 24, 2017 at 7:06:06 AM EDT To: Subject: FOURIER: Significant LDL Reduction with Evolocumab Reply-To: Cardiology Alert E— ail not displaying conectly?View ... your browser. FOURIER: Significant LDL Reduction with Evolocumab New data from the Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) study, presented

https://www.justice.gov/epstein/files/DataSet%209/EFTA00447984.pdf

EFTA00447981Set 9

2017-03-243p1,031w

From: ' To: Lesley Groff Subject: Fwd: FOURIER: Significant LDL Reduction with Evolocumab Date: Fri, 24 Mar 2017 11:17:36 +0000 Lesley please forward to Jeffrey rs Rony Shimony ... Subject: FOURIER: Significant LDL Reduction with Evolocumab Reply-To: Cardiology Alert <I Email not displaying correctyNiaw it in your browser. FOURIER: Significant LDL Reduction with Evolocumab New data from ... Scientific Session in Washington, M. suggested that evolocumab was associated with significant reductions in LDL cholesterol in patients with atherosclerotic cardiovascular disease and elevated LDL. The PCSK9 inhibitor evolocumab

https://www.justice.gov/epstein/files/DataSet%209/EFTA00447981.pdf

EFTA00287152Set 9

2016-09-149p2,942w

Serum; Test Code Change; Venipuncture TESTS RESULT FLAG UNITS REFERENCE INTERVAL LAS tiHR LipoProfile LDL Particle Number 01 LDL-P 1562 High nmol/L <1000 01 Low < 1000 Moderate ... Borderline -High 1300 - 1599 High 1600 - 2000 Very High > 2000 Lipids 01 LDL-C mg/dL 0 - 99 Triglyceride result indicated is too high for an accurate LDL cholesterol estimation. Optimal ... optimal 100 - 129 Borderline 130 - 159 High 160 - 189 Very high 189 comment: 01 LDL-C is inaccurate if patient is non-fasting. HDL-C 27 Low mg/d1

https://www.justice.gov/epstein/files/DataSet%209/EFTA00287152.pdf

EFTA01071103Set 9

11p1,803w

other 30% (termed "hyper responders"), eggs can mildly raise Total and LDL cholesterol. However, as I will outline later in the article, the situation is a bit more complicated than ... incredibly important but most people aren't getting enough of. 5. Eggs Turn LDL Cholesterol From Small, Dense to Large, Linked to a Reduced Risk of Heart Disease 9 LDL ... known as the "bad" cholesterol. It is well known that having high levels of LDL is linked to an increased risk of heart disease. But what many people

https://www.justice.gov/epstein/files/DataSet%209/EFTA01071103.pdf

EFTA01108234Set 9

2013-09-2513p3,639w

Order; Ferritin, Serum; Request Problem TESTS RESULT FLAG UNITS REFERENCE INTERVAL LAB N1414 LipoProfile LDL Particle Number 01 LDL-P 2111 High nmol/L <1000 01 Low < 1000 Moderate ... Borderline-High 1300 - 1599 High 1600 - 2000 Very High > 2000 Lipids 01 LDL-C NOTES: mg/dL <100 01 LDL-C cannot be calculated because triglycerides are > 400 mg/dL. Optimal ... mg/dL >=40 01 Triglycerides High mg/dL <150 01 Cholesterol, Total High mg/dL <200 01 LDL and HDL Particles 01 HDL-P (Total) 28.7 Low umol/L >= 30.5 01 Small LDL

https://www.justice.gov/epstein/files/DataSet%209/EFTA01108234.pdf

EFTA00304964Set 9

2013-09-2513p3,569w

Order; Ferritin, Serum Request Problem TESTS RESULT FLAG UNITS REFERENCE INTERVAL LAB NMR LipoProfile LDL Particle Number 01 LDL-P 2111 High nmol/L <1000 01 Low < 1000 Moderate ... Borderline-High 1300 - 1599 High 1600 - 2000 > 2000 Very High Lipids 01 LDL-C NOTES: mg/dL <100 01 LDL-C cannot be calculated because triglycerides are > 400 mg/dL. Optimal ... mg/dL >=40 01 Triglycerides High mg/dL <150 01 Cholesterol, Total High mg/dL <200 01 LDL and HDL Particles 01 HDL-P (Total) 28.7 Low umo3/L >= 30.5 01 Small

EFTA00620069Set 9

26p10,915w

have all been led to believe that the underlying issue is too much LDL cholesterol—which is essentially the amount of cholesterol carried in your low-density lipoproteins (LDL ... growing amount of research suggests that this is not entirely true. Every LDL particle carries on its surface a type of protein known as apoB, which distinguishes LDL particles—those ... Briefly, this is what causes atherosclerosis (at the molecular level): apoB-bearing lipoproteins (mostly LDL particles, but also VLDL particles and Lp(a) particles in those with high numbers

https://www.justice.gov/epstein/files/DataSet%209/EFTA00620069.pdf

EFTA00635610Set 9

2017-02-0535p11,640w

heart disease may actually be related to cholesterol sulfate deficiency, and explains how elevated LDL cholesterol is a sign of this deficiency. In short, high LDL (incorrectly referred ... cholesterol) is your body's way of compensating for cholesterol sulfate deficiency. When LDL is turned into plaque, blood platelets inside the plaque produce cholesterol sulfate, which your heart ... brain needs for optimal function. This also explains why lowering LDL with statins can lead to heart failure. Essentially, by elevating LDL, your body is protecting itself from the harmful

https://www.justice.gov/epstein/files/DataSet%209/EFTA00635610.pdf

EFTA01108062Set 9

2011-07-2715p3,795w

Range Reference Range Lab VAP (TM) CHOLESTEROL TEST DIRECTLY MEASURED LIPID ATT TOTAL LDL-C DIRECT 99 <130 mg/dL (Desirable range <100 mg/dL for CHD, Diabetes, or its equivalent) TOTAL ... Triglycerides may be elevated if p Tent has not fasted. TOTAL NON-1410L-C(LDL+VLDL) 161 H <160 mg/dL FOR SETTING LDL-C GOAL ATT LP(a) CHOLESTEROL ... mg/dL IDL-C 25 H <20 mg/dL REAL-LDL-C 67 <100 mg/dL SUM TOTAL LDL-C 99 <130 mg/dL REAL-LDL SIZE PATTERN A A ( 1I 1 I Pattern

https://www.justice.gov/epstein/files/DataSet%209/EFTA01108062.pdf

EFTA00674918Set 9

2015-07-245p2,152w

EFTA00674918 treat patients who have been extremely difficult to treat with high levels of LDL cholesterol," says Steven Nissen, chairman of cardiology at the Cleveland Clinic. "It's very promising ... ODYSSEY LONG TERM trial which evaluated Praluent 150 mg every two weeks, Praluent reduced LDL cholesterol by 58 percent versus placebo at week 24 when added to current standard ... Praluent 75 mg every two weeks as an adjunct to statins EFTA00674920 reduced LDL cholesterol by an additional 46 percent compared to placebo at week 12. At week

https://www.justice.gov/epstein/files/DataSet%209/EFTA00674918.pdf

EFTA00850478Set 9

2015-07-243p2,367w

treat patients who have been extremely difficult to treat with high levels of LDL cholesterol," says Steven Nissen, chairman of cardiology at the Cleveland Clinic. "It's very promising ... ODYSSEY LONG TERM trial which evaluated Praluent 150 mg every two weeks. Praluent reduced LDL cholesterol by 58 percent versus placebo at week 24 when added to current standard ... COMBO 1, Pralucnt 75 mg every two weeks as an adjunct to statins reduced LDL cholesterol by an additional 46 percent compared to placebo at week 12. At week

https://www.justice.gov/epstein/files/DataSet%209/EFTA00850478.pdf

EFTA00804474Set 9

2018-11-236p1,814w

CHOLESTEROL 23 L >40 mg/dL MI TRIGLYCERIDES 935 H <150 mg/dL MI LDL-CHOLESTEROL mg/dL (talc) MI LDL cholesterol not calculated. Triglyceride levels greater than 400 mg/dL invalidate calculated LDL ... mg/dL for patients with CHD or diabetic patients with > or = 2 CHD risk factors. LDL-C is now calculated using the Martin-Hopkins calculation, which is a validated novel method ... providing better accuracy than the Friedewald equation in the estimation of LDL-C. Martin SS et al. JAMA. 2013;310(19): 2061-2068 (http://education.QuestDiagnostics.com/faq/FAQ164) CHOL/HDLC RATIO

https://www.justice.gov/epstein/files/DataSet%209/EFTA00804474.pdf

EFTA00304870Set 9

2018-08-145p1,405w

CHOLESTEROL 29 L >40 mg/dL MI TRIGLYCERIDES 541 H <150 mg/dL MI LDL-CHOLESTEROL mg/dL (calc) MI LDL cholesterol not calculated. Triglyceride levels greater than 400 mg/dL invalidate calculated LDL ... mg/dL for patients with CHD or diabetic patients with > or = 2 CHD risk factors. LDL-C is now calculated using the Martin-Hopkins calculation, which is a validated novel method ... providing better accuracy than the Friedewald equation in the estimation of LDL-C. Martin SS et al. JAMA. 2013;310(19): 2061-2068 (http://education.QuestDiagnostics.com/faq/FAQ164) CHOL/HDLC RATIO

https://www.justice.gov/epstein/files/DataSet%209/EFTA00304870.pdf

EFTA00304878Set 9

2018-08-305p1,343w

CHOLESTEROL 29 L >40 mg/dL MI TRIGLYCERIDES 475 H <150 mg/dL MI LDL-CHOLESTEROL mg/dL (talc) MI LDL cholesterol not calculated. Triglyceride levels greater than 400 mg/dL invalidate calculated LDL ... mg/dL for patients with CHD or diabetic patients with > or = 2 CHD risk factors. LDL-C is now calculated using the Martin-Hopkins calculation, which is a validated novel method ... providing better accuracy than the Friedewald equation in the estimation of LDL-C. Martin SS et al. JAMA. 2013;310(19): 2061-2068 (http://education.QuestDiagnostics.com/faq/FAQ164) CHOL/HDLC RATIO

https://www.justice.gov/epstein/files/DataSet%209/EFTA00304878.pdf

EFTA00317114Set 9

2018-08-035p1,375w

CHOLESTEROL 29 L >40 mg/dL MI TRIGLYCERIDES 855 H <150 mg/dL MI LDL-CHOLESTEROL mg/dL (talc) MI LDL cholesterol not calculated. Triglyceride levels greater than 400 mg/dL invalidate calculated LDL ... mg/dL for patients with CHD or diabetic patients with > or = 2 CHD risk factors. LDL-C is now calculated using the Martin-Hopkins calculation, which is a validated novel method ... providing better accuracy than the Friedewald equation in the estimation of LDL-C. Martin SS et al. JAMA. 2013;310(19): 2061-2068 (http://education.QuestDiagnostics.com/faq/FAQ164) CHOL/HDLC RATIO

https://www.justice.gov/epstein/files/DataSet%209/EFTA00317114.pdf

EFTA00804470Set 9

2018-11-234p1,128w

CHOLESTEROL 23 L >40 mg/dL MI TRIGLYCERIDES 935 H <150 mg/dL MI LDL—CHOLESTEROL mg/dL (talc) MI LDL cholesterol not calculated. Triglyceride levels greater than 400 mg/dL invalidate calculated LDL ... mg/dL for patients with CHD or diabetic patients with > or = 2 CHD risk factors. LDL-C is now calculated using the Martin-Hopkins calculation, which is a validated novel method ... providing better accuracy than the Friedewald equation in the estimation of LDL-C. Martin SS et al. JAMA. 2013;310(19): 2061-2068 (http://education.QuestDiagnostics.com/faq/FAQ164) CHOL/HDLC RATIO

https://www.justice.gov/epstein/files/DataSet%209/EFTA00804470.pdf

EFTA00304997Set 9

2018-01-055p1,467w

CHOLESTEROL 28 L >40 mg/dL MI TRIGLYCERIDES 510 H <150 mg/dL MI LDL-CHOLESTEROL mg/dL (talc) MI LDL cholesterol not calculated. Triglyceride levels greater than 400 mg/dL invalidate calculated LDL ... with CHD or diabetes and <70 mg/dL for diabetic patients with known heart disease. LDL-C is now calculated using the Martin-Hopkins calculation, which is a validated novel method ... providing better accuracy than the Friedewald equation in the estimation of LDL-C. Martin SS et al. JAMA. 2013;310(19): 2061-2068 (http://education.QuestDiagnostics.com/faq/FAQ164) CHOL/HDLC RATIO

https://www.justice.gov/epstein/files/DataSet%209/EFTA00304997.pdf

EFTA02234559Set 11

2018-01-176p1,232w

labs sent from early this month, Lipids done was calculated as opposed to direct LDL. Insurance companies look for the direct LDL when approving medications because this is a more ... such as in the case of Mr. Epstein, the lab cannot provide an accurate LDL count. As you can see there was no LDL value given -If you want ... proceed with insurance approval, he will need to re-take labs with direct LDL. He cannot start prior to rechecking labs because it will not be an accurate reflection

https://www.justice.gov/epstein/files/DataSet%2011/EFTA02234559.pdf

EFTA00314225Set 9

2018-08-1415p4,271w

CHOLESTEROL 29 L >40 mg/dL MI TRIOLTCERIDES 541 H <150 mg/dt MI LDL-CHOLESTEROL mg/dL (talc) MI LDL cholesterol not calculated. TrigLyceride levels greater than 400 mg/dL invalidate calculated ... mg/dL for patients with CHD or diabetic patients with > or • 2 CHD risk factors. LDL-C is now calculated using the Martin-Hopkins calculation, which is a validated novel method ... providing better accuracy than the Friedewald equation in the estimation of LDL-C. Mar ' • • 2 1-20 a CHOL DL RATIO <5.0 Coale) MI NON HDL CHOLESTEROL

https://www.justice.gov/epstein/files/DataSet%209/EFTA00314225.pdf