EFTA01140307Set 9
2012-02-284p3,580w
their way into formal newborn screening recommendations
ABSTRACT: In the traditional medical genetics setting,
metabolic disorders, identified either clinically or through [ACMG, 2006). Used for second-tier biochemical confirmation ... inform on disease over. Starting with phenylketonuria in 1953, nutritional therapeutics
guided by metabolic screening and serial testing has been conclu-
management, treatment, familial testing, and reproduc-
tive options ... milder manifestations of known tant to help verify pathogenicity. Of these, biochemical assays have
metabolic diseases. Metabolomic phenotyping in the Per- historically been the axis most frequently correlated with genetic
https://www.justice.gov/epstein/files/DataSet%209/EFTA01140307.pdf
EFTA01045495Set 9
2018-05-2936p8,101w
early stage may enhance brain vascular function,
increase beneficial gut microbiota, improve metabolic profile, and reduce risk for AD.
Introduction
EFTA01045495
Neurovascular functions play a critical role in determining cognitive ... reduced or ketogenesis is increased40. Similar to
caloric restriction, mTOR inhibition can preserve brain metabolism with ageil,
potentially due to the shift from glucose to ketone body utilization42 ... addition, shotgun metagenome and
metatranscriptome sequencing efforts will be required to associate specific metabolic
capabilities (e.g., SCFAs production) with identified taxa, and to demonstrate where
and when these genes
https://www.justice.gov/epstein/files/DataSet%209/EFTA01045495.pdf
EFTA00620069Set 9
26p10,915w
will die from one of four chronic diseases that share the same underlying
metabolic derangement are at least 4 in 5!
Think about that for a moment. Four diseases. Which ... that you and I face a
greater risk of dying from The Big Four metabolic diseases: coronary heart disease,
cerebrovascular disease, cancer, and Alzheimer's disease
In other words ... aging as much as
possible, the probability that you will die of a metabolic disease—those strongly associated
with and exacerbated by obesity and type 2 diabetes—is north
https://www.justice.gov/epstein/files/DataSet%209/EFTA00620069.pdf
EFTA00611136Set 9
2013-12-1915p10,933w
reversible. of SIRT1 reproduces many of the health benefits of CR, including
protection from metabolic decline, cardiovascular disease, can-
INTRODUCTION cer. and neurodegeneration (Haigis and Sinclair, 2010: Libert and
Guarente ... cells with sufficient substrates Knockout of SIRT1 Mimics Aging by Decreasing
for biomass. This metabolic reprogramming, known as the Mitochondria!, but Not Nuclear-Encoded, OXPHOS
Warburg effect (Warburg ... part of retrograde response (Bell et al., 2007).
lytic fibers (MyHCllb) (Figure S1F). These metabolic changes Six hours after inducing SIRTI deletion in primary myoblasts,
were reminiscent of Warburg remodeling
https://www.justice.gov/epstein/files/DataSet%209/EFTA00611136.pdf
EFTA00625051Set 9
40p15,170w
ethinyl estradiol occurring 1 to 4
hours postdose. Both are subject to first-pass metabolism after oral dosing, resulting in
an absolute bioavailability of approximately 64% for norethindrone ... albumin. Although ethinyl
estradiol does not bind to SHBG, it induces SHBG synthesis.
Metabolism
Norethindrone undergoes extensive biotransformation, primarily via reduction, followed
by sulfate and glucuronide conjugation. The majority ... with glucuronides accounting for most of the urinary metabolites.
Ethinyl estradiol is also extensively metabolized, both by oxidation and by conjugation
with sulfate and glucuronide. Sulfates are the major circulating
https://www.justice.gov/epstein/files/DataSet%209/EFTA00625051.pdf
EFTA01110707Set 9
22p7,189w
Muscular
Dystrophy Phase I Protocol, Columbus, OH
2007 NIH Study Section, Inborn Errors Of Metabolism, Bethesda, MD
2008 Executive Committee, UMDNJ-SOM, Stratford, NJ
2008 Recruitment Committee, UMDNJ-SOM, Stratford ... Duchenne Muscular, 2006
Dystrophy Phase I Protocol
NIH Study Section- Inborn Errors Of Metabolism, 2007
Duchenne Muscular Dystrophy Grants, 2009
Partnership For Cures, 2009
Medical School/University
Search Committee for Associate ... System, 2005
INVITED SPEAKER — SCIENTIFIC MEETINGS
2000 Hunter's Hope Conference, IL, USA
2001 Metabolic Disorder Conference, Netherland
2001 Late Onset Tay Sachs Conference, PA USA
2002 European Pediatric Conference
https://www.justice.gov/epstein/files/DataSet%209/EFTA01110707.pdf
EFTA01122595Set 9
3p1,745w
first time definitive
molecular and genetic evidence for the critical role of metabolism in the pathogenesis of pulmonary
F:vangelos D. ichelaki.s. MD. FACC, FAHA
Professor and Vice Chair (Research ... skid ALBERTA Division of Cardiology
hypertension. He proposed that mitochondria (the regulators of metabolism) can integrate many diverse
decisions and activate or supress cell death accordingly. Paradoxically, while the mitochondria ... This work exposed several therapeutic targets. Gopinath also
inhibited these targets with clinically used metabolic modulators and was able to reverse mice and rat
pulmonary hypertension, as well as reverse
https://www.justice.gov/epstein/files/DataSet%209/EFTA01122595.pdf
EFTA02351022Set 11
2016-05-153p1,064w
blood by
metabolomics approach being imposed on our academic expert-se in molecular metabolism of ageing.
In the production workflow we utilise bl=od metabolomics technology for identification ... etabolic
information integrator. From such analysis imposed on our know-wh= on human molecular metabolism, we are able to
determine the impact of par=icular metabolites on the developmental trajectory ... indi=ate the precise molecular targets for personalised fine tuning of ageing
metabolism. Additionally, to expand availability of our ser=ice and to make it distance-independent, we plan
https://www.justice.gov/epstein/files/DataSet%2011/EFTA02351022.pdf
EFTA01092027Set 9
2013-10-125p2,524w
cells do not have a systemic effect and are not dependent upon the metabolic activity of
living cells for its activity, or (ii) they have a systemic effect ... dependent upon the metabolic
activity for its primary function, and are for autologous, allogeneic, or reproductive use.
The last criterion is two-pronged, but only one prong must be satisfied ... second prong.
The MSCs have a systemic effect and are dependent on the metabolic activity of the living cells (production
of cell factors that speed up wound healing
https://www.justice.gov/epstein/files/DataSet%209/EFTA01092027.pdf
EFTA01091480Set 9
2014-12-0511p3,697w
Education
Ph.D. (2008 - 2013) Electrical Engineering, McGill University, Montreal, Canada
2009 - 2010 - Institute of Metabolic Science, University of Cambridge, UK (visitor)
2010 - 2012 - Montreal Institute for Clinical Research, Montreal, Canada ... Refereed Journal Publications': [8, 9, 14, 17].
10/2009 — 09/2010 PhD Visitor Student. Institute of Metabolic Science, University of Cambridge
Refereed Journal Publications': [4, 6, 7, 13].
08/2006 — 05/2008 Master ... Remi Rabasa-Lhoret (Montreal Institute for Clinical Research); 2) Roman
Hovorka (Institute of Metabolic Science, University of Cambridge); 3) Benoit
Boulet (Department of Electrical and Computer Engineering, McGill University
https://www.justice.gov/epstein/files/DataSet%209/EFTA01091480.pdf
EFTA00625612Set 9
2017-01-2931p11,722w
milk, whey and casein, have the ability to preserve lean
muscle mass and improve metabolic health during weight loss, according to
research published in the journal Nutrition & Metabolism ... among Alaska Natives to 24.1% among American
Indians in southern Arizona.
Diabetes is a metabolic diseases in which there are high blood sugar levels
over a prolonged period. Symptoms ... digestive issues and others) can
also impact your body's ability to absorb and metabolize nutrients,
potentially raising your risk for deficiencies, as can diets that restrict
certain foods, such
https://www.justice.gov/epstein/files/DataSet%209/EFTA00625612.pdf
EFTA00828851Set 9
2016-04-2440p12,929w
Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in
which the person has high blood glucose (blood sugar), either because insulin production ... causes the body to release chemicals
that can destabilize the body's cardiovascular and metabolic systems.
Being overweight, physically inactive and eating the wrong foods all contribute to our risk ... circulatory system and the heart may already have occurred.
Diabetes is a metabolism disorder
Diabetes (diabetes mellitus) is classed as a metabolism disorder. Metabolism refers to the way our
bodies
https://www.justice.gov/epstein/files/DataSet%209/EFTA00828851.pdf