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EFTA01045495Set 9

2018-05-2936p8,101w

jeevacation@gmad.com> Subject: Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice I Scientific Reports Date: Tue, 29 May 2018 19:09:21 +0000 Ketogenic diet enhances ... neurovascular function with altered gut microbiome in young healthy mice 27 April 2018 Abstract Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB) function, plays a major ... microbiome and enhance neurovascular functions, and thus reduce risk for neurodegeneration in young healthy mice (12-14 weeks old). Here we show that with 16 weeks of KD, mice

https://www.justice.gov/epstein/files/DataSet%209/EFTA01045495.pdf

EFTA00611136Set 9

2013-12-1915p10,933w

Mammalian sirtuins (SIRT1-7) are a conserved family of NAD- - HAD' levels in old mice restores mitochondrial dependent lysine-modifying acylases that control physiological function to that of a young ... Deng, 2012). Interestingly, SIRT1 increases HIF-1a encoded OXPHOS components in aged mice might be due. in transcriptional activity (Lim et al.. 2010), SIRT3 destabilizes part, to a loss ... study, we provide evidence for a PGC-1a/11-indepen- reduced in the SIRT1 iKO mice compared to wild-type controls dent pathway of mitochondria' regulation that plays a role

https://www.justice.gov/epstein/files/DataSet%209/EFTA00611136.pdf

EFTA00987535Set 9

2014-04-145p2,905w

microbiome-gut-brain axis." published in Gastroenterology in 2011. Bercik and colleagues gave BALB/c mice, a strain of mice that are typically timid and shy, a cocktail of antibiotics, dramatically ... normal. In a follow-up experiment, Bercik's team corralled two strains of mice born and raised in a sterile environment: timid BALB/c mice, and NIH Swiss mice, known ... their courageous, exploratory behavior. The researchers then colonized each group of these "germ-free mice with bacteria from mice of the opposite strain. The result of this microbial swap

https://www.justice.gov/epstein/files/DataSet%209/EFTA00987535.pdf

EFTA02702554Set 11

ErbB4 suppresses Src upregulation ofNMDA receptors" published in "Nature Medicine". Their study of mice models investigates a potential link between glutamatergic dysfunction and the candidate schizophrenia genes NRGI and ErbB4 ... Buxbaum, 2004: p.575). This occurred as a discrepancy with an early study of mice lacking one copy of NRGI (NRG') gene and who displayed behavioral symptoms pertaining to schizophrenia including ... candidate schizophrenia genes NRGI and ErbB4. Their study of mouse models revealed that mice are either heterozygous for one of the susceptibility genes (NRGI or ErbB4), whereas mice with overexpression

https://www.justice.gov/epstein/files/DataSet%2011/EFTA02702554.pdf

EFTA02713009Set 11

2014-04-107p5,082w

infects enteric neuron and mucosal nerve fibers within the gastrointestinal tract in mice. Virology R M Gesser and S C Koo J. Virol. 1996, 70(6):4097. Updated information ... Type 1 Infects Enteric Neurons and Mucosal Nerve Fibers within the Gastrointestinal Tract in Mice R. M. OESSER,12* AND S. C. KOOI Division of Allergy, Itnnuutology. and Infectious Diseases ... mised (1, 8, 13, 26. 38). We have recently shown that HSV-1, In mice after oral inoculation, HSV-1 infects myenteric and orally inoculated into the esophageal lumen

https://www.justice.gov/epstein/files/DataSet%2011/EFTA02713009.pdf

EFTA00799222Set 9

Early, Region Specific Loss of Synapses in AD Models Hippocampus of 3 month J20 Mice Synaptophysin PSD95 co 150— Dentate Gyrus ... Bonferroni posttest EFTA00799252 Early Increased Deposition to PSD95+ Synapse in Hippocampus of AD Mice 400 S, 300 200 (,?, 100 EFTA00799253 Does Inhibition of Microglia- Synaptic Pruning Rescue Synapse Loss ... Memory and Cognitive tests EFTA00799254 C3 Deficiency Protects Against Synapse Loss in APP/PS1 Mice (4 m and 16 m) APP/PS1xC3 KO Synaptophysin + PSD95 Co-Localized Puncta

https://www.justice.gov/epstein/files/DataSet%209/EFTA00799222.pdf

EFTA00611569Set 9

2013-04-266p6,298w

Slc9a1 localizes to presynaptic nerve terminals of GABAergic neurons [54.70.711. Disruption of Slc9a1 in mice re- sulted in a severe phenotype with locomotor deficits, epileptic sei- zures. neurodegeneration, and early ... recov- ery from acid loads 1741. The epileptic phenotype in Slc9a1 knock- Slc4a8 out mice is therefore surprising, because an increase in pH is SNAP25 generally associated with an increase ... characterization lular pH buffering on the spontaneous release of GABAergic vesi- of Slc4a8 knockout mice [411 and confirmed in an independent cles in cerebellar granule cells was investigated. The results

https://www.justice.gov/epstein/files/DataSet%209/EFTA00611569.pdf

EFTA01193329Set 9

2015-08-306p1,638w

brain. I studied deficits in synaptic plasticity and leaming/memory behaviors in various gene-knockout mice. My research results had been published in Science, Cell, Neuron, and Annual Reviews of Neuroscience ... motor dysfunctions. Studied genetic. molecular cellular and behavioral mechanisms underlying learning & memory in mice. EFTA01193331 Holistic Health Care 2001—Present. Founder/Director, Chi Wellness Clinic, Boston, MA. Research, development and administration ... Chen, C., et al. 1994. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-CaM kinase II. Science 266, 291-294. Chen, C (1995). Wagnerian genetics. Response

https://www.justice.gov/epstein/files/DataSet%209/EFTA01193329.pdf

EFTA00586622Set 9

2015-08-306p1,638w

brain. I studied deficits in synaptic plasticity and leaming/memory behaviors in various gene-knockout mice. My research results had been published in Science, Cell, Neuron, and Annual Reviews of Neuroscience ... motor dysfunctions. Studied genetic. molecular cellular and behavioral mechanisms underlying learning & memory in mice. EFTA00586624 Holistic Health Care 2001—Present. Founder/Director, Chi Wellness Clinic, Boston, MA. Research, development and administration ... Chen, C., et al. 1994. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-CaM kinase II. Science 266, 291-294. Chen, C (1995). Wagnerian genetics. Response

https://www.justice.gov/epstein/files/DataSet%209/EFTA00586622.pdf

EFTA01103908Set 9

This created a Hauser Chapter 1. Nature's secrets 70 EFTA01103927 new line of mice with a special accessory: an upgraded memory and learning system. When these new and improved ... mice ran through an IQ test, they outperformed normal mice. Tsien pulled off an extraordinary engineering trick, creating a lineage of smarter mice. This is cowboy science, showing the power ... world of competition, one would imagine that selection should favor these smart mice who have better recall of essential foraging routes, previous social interactions, and places to rest

https://www.justice.gov/epstein/files/DataSet%209/EFTA01103908.pdf

EFTA02031516Set 10

2011-11-053p841w

related diseases, a new study has found. When researchers removed such cells from mice, they were able to delay the onset of cataracts and slow agc-rclatcd muscle loss. "This ... says. Van Deursen and colleagues developed a way to kill senescent cells in mice, clearing them from the body. They engineered mice so that when cells flipped on a gene ... death genes, not normally produced by senescent cells. Then, when the researchers gave the mice a drug. the death pathway would be activated in all senescent cells. "Our method allowed

https://www.justice.gov/epstein/files/DataSet%2010/EFTA02031516.pdf

EFTA01008124Set 9

2017-09-258p3,646w

just aging) are the product of this aging. Experiments have shown that in mice the introduction of youthful cord plasma significantly improves the learning capability of mice (lots of cool ... tests with mice and mazes, where the young mice zip through the old mice just sit there until they are treated with plasma). There is interesting work on the cellular ... later date. This discovery has led to the idea of creating "false" memories in mice (sort of a Total Recall for mice). In one experiment the ability for a mouse

https://www.justice.gov/epstein/files/DataSet%209/EFTA01008124.pdf

EFTA00640752Set 9

2017-09-255p2,564w

just aging) are the product of this aging. Experiments have shown that in mice the introduction of youthful cord plasma significantly improves the learning capability of mice (lots of cool ... tests with mice and mazes, where the young mice zip through the old mice just sit there until they are treated with plasma). There is interesting work on the cellular ... later date. This discovery has led to the idea of creating "false" memories in mice (sort of a Total Recall for mice). In one experiment the ability for a mouse

https://www.justice.gov/epstein/files/DataSet%209/EFTA00640752.pdf

EFTA01202731Set 9

2014-03-3035p16,850w

retinal health and vision. To test that possibility, the researchers gathered adult, healthy lab mice. Half of these were allowed to remain sedentary throughout the day, while the other animals ... rodent pace for about an hour a day. After two weeks, half of the mice in each group were exposed to a searingly bright light for four hours. The other ... obviously. But it causes a comparable if time-compressed loss of retinal neurons. The mice then returned to their former routine — running or not exercising — for another two weeks, after

https://www.justice.gov/epstein/files/DataSet%209/EFTA01202731.pdf

EFTA01105942Set 9

makeup, can punch through both spaceships and the astronauts inside. EFTA01105946 Mice were given a dose of radiation similar to what those astronauts would experience in a trip to Mars ... mice that were exposed to the radiation were far less likely to respond positively to a series of experiments and also had enflamed blood vessels. One promising fact ... experiment is the rate the dose of radiation was administered to the mice. They hit the mice with the entire dose in a few minutes while astronauts would receive

https://www.justice.gov/epstein/files/DataSet%209/EFTA01105942.pdf

EFTA01802986Set 10

2011-11-053p867w

related dise=ses, a new study has found. When researchers removed such cells from mice,=they were able to delay the onset of cataracts and slow age-related muscle=loss ... Deursen and colleagues developed a way to kil= senescent cells in mice, clearing them from the body. They engineered mic= so that when cells flipped on a gene called p161nk4a ... genes, not normally produced by senescent cells. Then, w=en the researchers gave the mice a drug, the death pathway would be activa=ed in all senescent cells

https://www.justice.gov/epstein/files/DataSet%2010/EFTA01802986.pdf

EFTA01120876Set 9

2013-08-1410p4,146w

team tested the significance of the specific microRNA strands on a group of injured mice. In one batch, they let the mice's muscles heal naturally. In another, they "sponged ... adversely affected the healing process. The difference was remarkable. "In those mice, the differentiation was really poor," he said of the latter group. "What we found in these cells ... microRNA back in." Except he may no longer have mice on which to take that next step. Leaning forward in his office chair, he confides that if he wants

https://www.justice.gov/epstein/files/DataSet%209/EFTA01120876.pdf

EFTA00620069Set 9

species-from the tiny bacterium whose lifecycle is measured in minutes, to mosquitos (days), mice (months), birds (years), humans (decades), turtles/tortoises (perhaps centuries), and even to bristlecone pine (millennia). Clearly ... response seen in rats and ringworms; little to none seen in many strains of mice), it has been widely documented that 20 to 40 percent caloric restriction (CR) increases longevity ... accompanying weight loss, which may actually be a downside. For example, in mice (a species that typically doesn't respond as favorably as others to CR), the mice that lose

https://www.justice.gov/epstein/files/DataSet%209/EFTA00620069.pdf

EFTA02690271Set 11

2011-07-0226p7,257w

remarkable balance between calories consumed and calories burned was observed. When various mammals, from mice to monkeys, are either overfed or starved for a few weeks, their weight soon returns ... scientists using genetic tricks but arose spontaneously in a breeding colony.) Both strains of mice were extremely fat, a trait that was passed on to their offspring in a simple ... EFTA_R1_02030168 EFTA02690294 25 able to track down the mutation in the obese mice and found that it blocked production of a particular protein hormone, which they named leptin

https://www.justice.gov/epstein/files/DataSet%2011/EFTA02690271.pdf

EFTA00711072Set 9

2013-12-203p586w

after identifying a natural compound proven to rewind the effects of old age in mice. A protein found in all living cells called NAD could be the key to slowing ... slowing down the ageing process Tests on two-year-old mice who had been given the NAD-producing compound for just one week had body tissue which resembled that ... ageing may be reversible if caught early.' EFTA00711073 ice: Tests on two-year-old mice who had been given the compound for one week had tissue which resembled six- month

https://www.justice.gov/epstein/files/DataSet%209/EFTA00711072.pdf

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