were 45% and 57%,
respectively.
Renal Insufficiency: In volunteers with mild (CLcr=50-80 mUmin) and moderate
(CLcr=30-49 mUmin) renal impairment, the pharmacokinetics of a single oral dose ... VIAGRA
(50 mg) were not altered. In volunteers with severe (CLcr=c30 mUmin) renal impairment,
sildenafil clearance was reduced, resulting in approximately doubling of AUC and C.
compared ... patients: age >65,
hepatic impairment (e.g., cirrhosis), severe renal impairment (e.g., creatinine clearance
<30 mUmin), and concomitant use of potent cytochrome P450 3A4 inhibitors (erythromycin),
plasma levels of sildenafil