predominantly mediated via
the chloride/base exchangers DRA (Down Regulated in Adenoma) (SLC26A3) and PAT1 (Putative Anion
Transporter I) (SLC26A6), and the Na(+) /H(+) exchanger NHE3 (Sodium Hydrogen Exchanger3) (SLC9A3).
PAT1 ... salt absorption in the jejunum and kidney tubules, responses that were significantly diminished in
PAT1 null mice. These studies further demonstrated that GlutS (SLC2A5) is the major fructose-absorbing
transporter ... fructose. Increased dietary fructose intake for several weeks upregulated the expression of NHE3,
PAT1 and GlutS in the intestine and resulted in hypertension in wild-type mice, a response that