steady-state with
respect to ethinyl estradiol was reached by Day 13.
Mean SHBG concentrations were increased by 150% from baseline (57.5 nmol/L) to 144
nmol/L at steady-state ... Single EE 64.5 (27) 1.3 (0.7-4.0) 465.4 (26) -- -- --
Dose)
SHBG - .... - 57.5 (37)b -- --
NE 16400 (26) 1.3 (0.7-4.0) 88160 (30) 880 (51) 8.4 3670 (30)
Day 24
(Multiple ... Dose)
SHBG -- -- -- 144 (24) -- --
Cmax = Maximum plasma concentration t.= Time of C. ; = m'nimum plasma concentration at steady-state
; AUC(0241 = Area under plasma concentration versus time curve from