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Meyer-Overton rule. Agents, such as 1,3,5 tris(trifluoromethyl)senzene (TFMB) and 1,2 dichlorohexafluorocyclobutane (F6), which are predicted by their lipid solubility to have significant anesthetic potency ... polarizability correlation also implies that the predicted MAC of the non-anesthetics F6 and TFMB are less than predicted by the Meyer-Overton relation suggesting an even higher anesthetic potency ... hypothesis by assessing the effects of several volatile anesthetics, the non-anesthetics F6 and TFMB, as well as the convulsant flurothyl on the London dispersion interactions between highly polarizable aromatic