EFTA00506070Set 9
2013-08-2236p3,940w
Program 2013 2014 2015 2016 2017 2018 2019
l Il l
EPB-348 I
VZV-Shingles Pt 2t0Pi r Tra Pi Items; TT.I Atcrvo3 Mao Clogintrg
-I —
EBV-Transplant ... provide consistent rationale
why EPB-348 is more potent than other antivirals
Active Drug
VZV Welts
1j1 •
EP8-348
l. •
142G
thkintsciclovii Stn. wal YAsDNA
iptoditvg) Thyrnitine
Polymerise
Kings.O ... 400x more potent than acyclovir (ACV)
• H2G is approx. 250x-better substrate for VZV encoded thymidine kinase than ACV
• The intracellular concentration of H2G-TP is more than 140x greater
https://www.justice.gov/epstein/files/DataSet%209/EFTA00506070.pdf