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EFTA02714282Set 11

8p3,952w

conventional drugs. One method to target disease-causing proteins involves developing small interfering RNA (siRNA) molecules that are developed to suppress the production of proteins through the RNAi mechanism. siRNA ... into the cell. The LNPs then undergo an interaction within the cell and the siRNA drug is released mediating RNAi. This technology has a series of benefits that improve effectiveness ... that cause individuals to avoid alcohol consumption. The Company has developed an extremely potent siRNA trigger combined with a third generation LNP. Although an ALDH2 inhibition drug already exists (Disulfiram

https://www.justice.gov/epstein/files/DataSet%2011/EFTA02714282.pdf

EFTA01197764Set 9

8p3,954w

conventional drugs. One method to target disease-causing proteins involves developing small interfering RNA (siRNA) molecules that are developed to suppress the production of proteins through the RNAi mechanism. siRNA ... into the cell. The LNPs then undergo an interaction within the cell and the siRNA drug is released mediating RNAi. This technology has a series of benefits that improve effectiveness ... that cause individuals to avoid alcohol consumption. The Company has developed an extremely potent siRNA trigger combined with a third generation LNP. Although an ALDH2 inhibition drug already exists (Disulfiram

https://www.justice.gov/epstein/files/DataSet%209/EFTA01197764.pdf

EFTA01196009Set 9

2p583w

Center, Carnegie Mellon University Undergraduate Research Assistant, September 2010 — May 2011 Thesis: Delivery of sIRNAs Using Cationic Nanostructured Star Polymers to Prevent Cell Differentiation to Bone Participated in a project ... determine the in vitro knockdown efficiency of anti-Runx-2, anti-OSx siRNAs delivered by cationic NSPs to prevent BMP-induced C2C12 cell differentiation. Maintained C2C12 cell cultures and assessed

https://www.justice.gov/epstein/files/DataSet%209/EFTA01196009.pdf

EFTA01595042Set 10

2p361w

limited Kolbe receipt of funis thrcitigh einctrnnsc kods transfer, by :heck, drat, cr any sirna.- rrstrument, that are reeled, docrlly or irldirecttp, t0 • -iiteret gambling P. Novel Use Only HYPCAJON

https://www.justice.gov/epstein/files/DataSet%2010/EFTA01595042.pdf

EFTA01200906Set 9

5p846w

couple from... Like • Comment ;•I'Broc Brock Pierce shared an article k Pierce sirna our next round of speakers for GamesBeat 2014: Total World ge for Domination Mike Gallagher

https://www.justice.gov/epstein/files/DataSet%209/EFTA01200906.pdf